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| First Name: | Mark E. | | Last Name: | Obrenovich | | Affiliation: | Case Western Reserve University | | Department: | Pathology | Country/Territory: | U.S.A. | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 24 May 2004]
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View all comments by Mark E. Obrenovich
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Alzheimer Disease, Prion Diseases, Aging Process, Parkinson Disease, Neurodevelopmental Disorders (Down syndrome, etc.), Tauopathies
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A-beta PP/A-beta, Oxidative Stress, Proteomics, Protein structure/chemistry, Chemistry/Pharmacology, Microscopy, Signal transduction, Molecular and Cell biology, Apoptosis/Cell cycle
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Biographical Sketch
Mark E. M. Obrenovich, B.Sc., M.Sc.
Graduate Student
Department of Pathology
Case Western Reserve University
Institute of Pathology
2085 Adelbert Rd,
Cleveland Ohio 44106
Phone: (216) 368-6238 FAX: (216) 368-0495
E-mail address: meo5@po.cwru.edu
Research interests: Mechanisms of aging, mortality, and longevity, Diabetes, Alzheimer Disease and Lenticular Aging and Cataractogenesis
Current status: Citizen of the United States.
EDUCATION:
Ph.D Cellular and Molecular Basis of Disease, 2003-present,
Case Western Reserve University, Cleveland, OH
M.Sc.: Cellular and Molecular Basis of Disease, 2003,
Case Western Reserve University, Cleveland, OH
Thesis Title: NeurofibrillaryTangles and Senile Plaques –Giving a “Voice” to Alzheimer Disease, January 2003.
Research Advisor: Professor Mark A. Smith
B.Sc.: Biology cum laude, 1994-1998, Cleveland State University, Cleveland, OH Two Time President’s Medal recipient
B.A.: Fine Arts cum laude, 1994-1998, Cleveland State University, Cleveland, OH President’s Medal recipient
A.A.: Social Science cum laude, 1989-1991, Bowling Green State University, Bowling Green, OH
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Mark E. Obrenovich and Vincent M. Monnier Glycation predisposes to amyloid formation Glycation offers new clues into the etiology of “conformational” diseases Science's SAGE KE Sci Aging Knowledge Environ. 2004 Jan 14;2004(2):pe3 http://sageke.sciencemag.org/cgi/.
Obrenovich ME., Smith M.A. Perry G. and Aliev G. Morphological features of the changes of arterial vessels endothelium after ischemia and following reperfusion. Journal of Submicr. Cytol. Pathol., 2004 (Revised).
Obrenovich ME., Smith M.A. Perry G. and Aliev G. Functional and Morphological characteristics of aortic endothelium by using different methods of their prevention after ischemia and hypoxia. Journal of Submicr. Cytol. Pathol., 2004 (Accepted for Publication).
Rutter K, Sell DR, Fraser N, Obrenovich M, Zito M, Starke-Reed P, Monnier VM. Green tea extract suppresses the age-related increase in collagen crosslinking and fluorescent products in C57BL/6 mice. Int J Vitam Nutr Res. 2003 Nov;73(6):453-60.
Mark E. Obrenovich and Vincent M. Monnier Vitamin B1 Blocks Damage Caused by Hyperglycemia Will thiamine offer a simple solution to complications of diabetes? Science's SAGE KE Sci Aging Knowledge Environ. 2003 Mar 12;2003(10):PE6, http://sageke.sciencemag.org/cgi/ .
Sell DR, Lane MA, Obrenovich ME, Mattison JA, Handy A, Ingram DK, Cutler RG, Roth GS, Monnier VM. The effect of caloric restriction on glycation and glycoxidation in skin collagen of nonhuman primates. J Gerontol A Biol Sci Med Sci. 2003 Jun;58(6):508-16.
Aliev G, Smith MA, Obrenovich ME, de la Torre JC, Perry G. Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease. Neurotox Res. 2003;5(7):491-504
Atwood CS, Obrenovich ME, Liu T, Chan H, Perry G, Smith MA, Martins RN. Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta Brain Res Brain Res Rev. 2003 Sep;43(1):1-16.
Obrenovich, M. E.; Raina, A. K.; Ogawa, O.; Atwood, C. S.; Smith, M. A. Alzheimer Disease – A New Beginning, Or A Final Exit?, Cell-Cycle Mechanisms in Neuronal Death Nicoletti, Ferdinando, Agata Copani Landis Biosciences (in press).
Monnier VM and Obrenovich ME. Wake up and smell the maillard reaction. Sci Aging Knowledge Environ. 2002 Dec 18;2002(50):pe21
Obrenovich, M. E.; Atwood, C. S.; Joseph, J. A.; Perry, G.; Smith, M. A. Amyloid-ß: A (Life) Preserver For The Brain, Neurobiology of Aging. Neurobiology of Aging. Dec 2002.
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Alternative views and a comprehensive understanding of the role of amyloid beta and tauopathies in AD. |
B. Bouma, L. M. Kroon-Batenburg, Y. P. Wu, B. Brunjes, G. Posthuma, O. Kranenburg, P. G. De Groot, E. E. Voest, M. F. Gebbink, Glycation Induces Formation of Amyloid Cross-Beta Structure in Albumin. J Biol Chem. 278, 41810-41819 (2003).
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Inhibitors of glycation to prevent amyloidosis or deglycating enzymes to treat AD |
Glycation and oxidative stress predispose to amyloidogenesis and impaired clearence by the ubiquitin-proteasome system in multi-disease systems. |
deglycation of amyloid plaques and intracellular inclusions would facilitate clearence of the deposits |
glycation is regulated to some extent and loss of endogenous protective regulatory mechanisms leads to accumulation of inclusions or deposits |
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